Drug Information

Drug General Information
Drug ID
D07IOB
Former ID
DIB021172
Drug Name
VU0092145
Synonyms
VU 0092145
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541399]
Structure
Download
2D MOL
Formula
C23H22N2O
InChI
InChI=1S/C23H22N2O/c1-16-12-14-19(15-13-16)25-22(17(2)18-8-4-3-5-9-18)24-21-11-7-6-10-20(21)23(25)26/h3-15,17,22,24H,1-2H3
InChIKey
QZAOSZVJAXUJFE-UHFFFAOYSA-N
PubChem Compound ID
4052597
PubChem Substance ID
5958650, 9448157, 24352984, 35312298, 48351806, 57303810, 80832073, 88341625, 103611078, 104108097, 106173643, 112608383, 118978058, 169285121, 178102850, 217593296
Target and Pathway
Target(s) Metabotropic glutamate receptor 4 Target Info Modulator (allosteric modulator) [529883]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Taste transduction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 541399(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6229).
Ref 529883Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead. Bioorg Med Chem Lett. 2009 Feb 1;19(3):962-6.

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