Drug Information
Drug General Information | |||||
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Drug ID |
D07DNV
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Former ID |
DIB007457
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Drug Name |
ARN-2966
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Synonyms |
ARN-2966; ARN-4261; Abeta aggregation inhibitors (Alzheimer's disease); Abeta aggregation inhibitors (Alzheimer's disease), New York University/Aria Neurosciences
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Drug Type |
Small molecular drug
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Indication | Alzheimer disease [ICD9: 331; ICD10:G30] | Investigative | [542536] | ||
Company |
New York University
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Structure |
Download2D MOL |
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Formula |
C12H12N2O
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InChI |
InChI=1S/C12H12N2O/c15-12-7-2-1-6-11(12)14-9-10-5-3-4-8-13-10/h1-8,14-15H,9H2
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InChIKey |
GXJRVWZNMZGWAQ-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Amyloid beta A4 protein | Target Info | Inhibitor | [543619] | |
KEGG Pathway | Notch signaling pathway | ||||
Alzheimer's disease | |||||
Reactome | Nuclear signaling by ERBB4 | ||||
Degradation of the extracellular matrix | |||||
Regulated proteolysis of p75NTR | |||||
NRIF signals cell death from the nucleus | |||||
Activated NOTCH1 Transmits Signal to the Nucleus | |||||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
EPH-ephrin mediated repulsion of cells | |||||
References |
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