Drug Information

Drug General Information
Drug ID
D07DAU
Former ID
DIB004342
Drug Name
Tafluposide
Synonyms
F-11782
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 1 [547025]
Company
Pierre Fabre SA
Structure
Download
2D MOL

3D MOL
Formula
C45H35F10O20P
Canonical SMILES
[C@H]1([C@H]([C@H]2[C@H](O[C@H]1O[C@H]1[C@@H]3[C@@H]([C<br />@@H](c4c1cc1c(c4)OCO1)c1cc(c(c(c1)OC)OP(=O)(O)O)OC)C(=O<br />)OC3)CO[C@H](O2)C)OC(=O)COc1c(c(c(c(c1F)F)F)F)F)OC(=O)C<br />Oc1c(c(c(c(c1F)F)F)F)F
PubChem Compound ID
70695621
Target and Pathway
Target(s) Toposisomerase-1 Target Info Modulator [526671]
DNA topoisomerase II Target Info Modulator [526671]
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway DNA replication
Pathway Interaction Database Caspase Cascade in Apoptosis
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 547025Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012192)
Ref 526671Ex vivo effects of the dual topoisomerase inhibitor tafluposide (F 11782) on cells isolated from fresh tumor samples taken from patients with cancer. Anticancer Drugs. 2003 Jul;14(6):467-73.

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