Drug Information

Drug General Information
Drug ID
D07CLV
Former ID
DIB018031
Drug Name
GDC-0152
Synonyms
GDC 0152; GDC0152
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Phase 1 [531843]
Structure
Download
2D MOL
Formula
C25H34N6O3S
InChI
InChI=1S/C25H34N6O3S/c1-16(26-2)22(32)27-21(18-12-7-4-8-13-18)25(34)31-15-9-14-19(31)23(33)28-24-20(29-30-35-24)17-10-5-3-6-11-17/h3,5-6,10-11,16,18-19,21,26H,4,7-9,12-15H2,1-2H3,(H,27,32)(H,28,33)/t16-,19-,21-/m0/s1
InChIKey
WZRFLSDVFPIXOV-LRQRDZAKSA-N
PubChem Compound ID
46940575
PubChem Substance ID
99448945, 120940012, 134356865, 134356867, 139764819, 160669643, 160868058, 163563926, 164178280, 164194057, 172650508, 198944039, 208265469, 223366066, 226088038, 235492068, 245767507
Target and Pathway
Target(s) X-linked inhibitor of apoptosis protein Target Info Modulator [531843]
KEGG Pathway NF-kappa B signaling pathway
Ubiquitin mediated proteolysis
Apoptosis
Focal adhesion
Toxoplasmosis
HTLV-I infection
Pathways in cancer
Small cell lung cancer
PANTHER Pathway Apoptosis signaling pathway
Pathway Interaction Database p75(NTR)-mediated signaling
BMP receptor signaling
Caspase Cascade in Apoptosis
TGF-beta receptor signaling
Reactome SMAC binds to IAPs
SMAC-mediated dissociation of IAP:caspase complexes
Deactivation of the beta-catenin transactivating complex
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Regulation of necroptotic cell death
WikiPathways Copper homeostasis
Focal Adhesion
Apoptosis
Intrinsic Pathway for Apoptosis
Apoptosis Modulation and Signaling
NOD pathway
References
Ref 531843Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). J Med Chem. 2012 May 10;55(9):4101-13.
Ref 531843Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). J Med Chem. 2012 May 10;55(9):4101-13.

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