Drug Information

Drug General Information
Drug ID
D07BYK
Former ID
DAP000488
Drug Name
Penciclovir
Synonyms
Adenovir; Denavir; Penciclovirum; Pencyclovir; Vectavir; BRL 39123; IN1162; MB2488; PE2; BRL-39123; Denavir (TN); Penciclovirum [INN-Latin]; Penciclovir & Human interferon-alpha; Penciclovir & Human interferon-beta; Penciclovir & Human interferon-gamma; Penciclovir (USAN/INN); Penciclovir [USAN:INN:BAN]; 2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one; 2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-1,9-dihydro-6H-purin-6-one; 2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-3,9-dihydropurin-6-one; 2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-3H-purin-6-one; 6H-Purin-6-one, 2-amino-1,9-dihydro-9-(4-hydroxy-3-(hydroxymethyl)butyl)-& Human interferon-alpha; 6H-Purin-6-one, 2-amino-1,9-dihydro-9-(4-hydroxy-3-(hydroxymethyl)butyl)-& Human interferon-beta; 6H-Purin-6-one, 2-amino-1,9-dihydro-9-(4-hydroxy-3-(hydroxymethyl)butyl)-& Human interferon-gamma; 9-(4-HYDROXY-3-(HYDROXYMETHYL)BUT-1-YL)GUANINE; 9-(4-Hydroxy-3-(hydroxymethyl)butyl)guanine; 9-(4-hydroxy-3-hydroxymethylbut-1-yl)-guanine; 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine; 9-[2-hydroxy-1-(hydroxymethyl)-ethoxymethyl]guanine; 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]guanine
Drug Type
Small molecular drug
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Approved [536361], [551871]
Therapeutic Class
Antiviral Agents
Structure
Download
2D MOL

3D MOL
Formula
C10H15N5O3
Canonical SMILES
C1=NC2=C(N1CCC(CO)CO)NC(=NC2=O)N
InChI
1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h5-6,16-17H,1-4H2,(H3,11,13,14,18)
InChIKey
JNTOCHDNEULJHD-UHFFFAOYSA-N
CAS Number
CAS 39809-25-1
PubChem Compound ID
4725
PubChem Substance ID
9621, 626312, 5433020, 7784770, 7889775, 7980269, 8152897, 12013576, 14774399, 15122289, 26719824, 26758052, 26759330, 29223811, 46386598, 46504797, 46506498, 47207082, 49681570, 50028164, 53800602, 57322416, 58107003, 76356225, 85246619, 91615544, 92308296, 92309147, 92710506, 103158227, 103567639, 104307247, 118046008, 118314778, 124658988, 124799997, 125349760, 126631814, 126658134, 126664331, 128301646, 131313494, 134213303, 134222457, 134337781, 135030805, 135260574, 137005929, 137035478, 141089745
SuperDrug ATC ID
D06BB06; J05AB13
SuperDrug CAS ID
cas=039809251
Target and Pathway
Target(s) DNA polymerase Target Info Inhibitor [537088]
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537088Antimicrobial strategies: inhibition of viral polymerases by 3'-hydroxyl nucleosides. Drugs. 2009;69(2):151-66. doi: 10.2165/00003495-200969020-00002.

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