Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07BRZ
|
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| Former ID |
DIB007857
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| Drug Name |
LY-517717
|
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| Drug Type |
Small molecular drug
|
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| Indication | Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] | Phase 2 | [521582] | ||
| Company |
Eli Lilly
|
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| Structure |
|
Download2D MOL |
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| Formula |
C27H33N5O2
|
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| Canonical SMILES |
CN1CCC(CC1)N2CCN(CC2)C(=O)[C@H](NC(=O)c3ccc4cc[nH]c4c3)<br />c5ccccc5
|
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| InChI |
1S/C27H33N5O2/c1-30-13-10-23(11-14-30)31-15-17-32(18-16-31)27(34)25(21-5-3-2-4-6-21)29-26(33)22-8-7-20-9-12-28-24(20)19-22/h2-9,12,19,23,25,28H,10-11,13-18H2,1H3,(H,29,33)/t25-/m1/s1
|
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| InChIKey |
VYNKVNDKAOGAAQ-RUZDIDTESA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Coagulation factor Xa | Target Info | Inhibitor | [531405], [531982] | |
| KEGG Pathway | Complement and coagulation cascades | ||||
| PANTHER Pathway | Blood coagulation | ||||
| Pathway Interaction Database | Beta2 integrin cell surface interactions | ||||
| PathWhiz Pathway | Coagulation | ||||
| Reactome | Extrinsic Pathway of Fibrin Clot Formation | ||||
| Intrinsic Pathway of Fibrin Clot Formation | |||||
| Common Pathway of Fibrin Clot Formation | |||||
| Gamma-carboxylation of protein precursors | |||||
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | |||||
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | |||||
| References | |||||
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