| Drug General Information |
| Drug ID |
D07ADR
|
| Former ID |
DNC003611
|
| Drug Name |
BOHEMINE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C18H24N6O
|
| InChI |
InChI=1S/C18H24N6O/c1-13(2)24-12-21-15-16(20-11-14-7-4-3-5-8-14)22-18(23-17(15)24)19-9-6-10-25/h3-5,7-8,12-13,25H,6,9-11H2,1-2H3,(H2,19,20,22,23)
|
| InChIKey |
OPQGFIAVPSXOBO-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
5510240, 8151618, 14875680, 26758319, 29217495, 29221586, 46511233, 48334281, 53800843, 57321309, 77284575, 81065550, 85787130, 99302647, 103024719, 103288934, 104300539, 121367066, 128843472, 134340816, 135314517, 141599071, 144233674, 162248323, 163079309, 163688513, 175607460, 178102561, 179148417, 204378336, 208265053, 225117139, 227654358, 252150308, 252451352
|
| Target and Pathway |
| Target(s) |
Cell division protein kinase 2 |
Target Info |
Inhibitor |
[2]
|
|---|
|
KEGG Pathway
|
FoxO signaling pathway
|
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Cell cycle
|
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Oocyte meiosis
|
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p53 signaling pathway
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PI3K-Akt signaling pathway
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Progesterone-mediated oocyte maturation
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Hepatitis B
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Measles
|
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Herpes simplex infection
|
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Epstein-Barr virus infection
|
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Pathways in cancer
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Viral carcinogenesis
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Prostate cancer
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Small cell lung cancer
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
|
p53 pathway
|
|
p53 pathway feedback loops 2
|
|
Pathway Interaction Database
|
Regulation of nuclear SMAD2/3 signaling
|
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Signaling events mediated by PRL
|
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p73 transcription factor network
|
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E2F transcription factor network
|
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ATR signaling pathway
|
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mTOR signaling pathway
|
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IL2-mediated signaling events
|
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FoxO family signaling
|
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FOXM1 transcription factor network
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BARD1 signaling events
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p53 pathway
|
|
Regulation of retinoblastoma protein
|
|
Reactome
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G0 and Early G1
|
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Activation of ATR in response to replication stress
|
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Regulation of APC/C activators between G1/S and early anaphase
|
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SCF(Skp2)-mediated degradation of p27/p21
|
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Senescence-Associated Secretory Phenotype (SASP)
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DNA Damage/Telomere Stress Induced Senescence
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Processing of DNA double-strand break ends
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G2 Phase
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Orc1 removal from chromatin
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Cyclin E associated events during G1/S transition
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Cyclin A/B1 associated events during G2/M transition
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p53-Dependent G1 DNA Damage Response
|
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Cyclin A:Cdk2-associated events at S phase entry
|
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Meiotic recombination
|
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Factors involved in megakaryocyte development and platelet production
|
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WikiPathways
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DNA Damage Response
|
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ID signaling pathway
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DNA Replication
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G1 to S cell cycle control
|
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M/G1 Transition
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S Phase
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Meiotic Recombination
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Aryl Hydrocarbon Receptor
|
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ATM Signaling Pathway
|
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Retinoblastoma (RB) in Cancer
|
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Spinal Cord Injury
|
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Integrated Pancreatic Cancer Pathway
|
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Oncostatin M Signaling Pathway
|
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Prostate Cancer
|
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Signaling Pathways in Glioblastoma
|
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TSH signaling pathway
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Integrated Breast Cancer Pathway
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Integrated Cancer pathway
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Synthesis of DNA
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Regulation of DNA replication
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Mitotic G2-G2/M phases
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Mitotic G1-G1/S phases
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Factors involved in megakaryocyte development and platelet production
|
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Cell Cycle
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APC/C-mediated degradation of cell cycle proteins
|
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Cell Cycle Checkpoints
|
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miRNA Regulation of DNA Damage Response
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5938). |
|---|
| REF 2 | J Med Chem. 2000 Jun 29;43(13):2506-13.Docking-based development of purine-like inhibitors of cyclin-dependent kinase-2. |
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