| Drug General Information |
| Drug ID |
D06YMT
|
| Former ID |
DIB003597
|
| Drug Name |
PLX-ORI3
|
| Synonyms |
PLX-ORI3; Omni-Raf inhibitors (cancer); Omni-Raf inhibitors (cancer), Plexxikon
|
| Indication |
Cancer [ICD9: 140-229; ICD10:C00-C96]
|
Investigative |
[1]
|
|---|
| Company |
Plexxikon Inc
|
| Target and Pathway |
| Target(s) |
mRNA of B-Raf |
Target Info |
Inhibitor |
[1]
|
|---|
| mRNA of RAF proto-oncogene serine/threonine-protein kinase |
Target Info |
Inhibitor |
[2]
|
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BioCyc Pathway
|
MAP kinase cascade
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KEGG Pathway
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MAPK signaling pathway
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ErbB signaling pathway
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Rap1 signaling pathway
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cAMP signaling pathway
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Chemokine signaling pathway
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FoxO signaling pathway
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mTOR signaling pathway
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Vascular smooth muscle contraction
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Focal adhesion
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Natural killer cell mediated cytotoxicity
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Long-term potentiation
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Neurotrophin signaling pathway
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Serotonergic synapse
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Long-term depression
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Regulation of actin cytoskeleton
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Insulin signaling pathway
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Progesterone-mediated oocyte maturation
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Alcoholism
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Hepatitis C
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Pathways in cancer
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Proteoglycans in cancer
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Colorectal cancer
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Renal cell carcinoma
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Pancreatic cancer
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Endometrial cancer
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Glioma
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Prostate cancer
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Thyroid cancer
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Melanoma
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Bladder cancer
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Chronic myeloid leukemia
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Acute myeloid leukemia
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Non-small cell lung cancerhsa04010:MAPK signaling pathway
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Ras signaling pathway
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cGMP-PKG signaling pathway
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Sphingolipid signaling pathway
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PI3K-Akt signaling pathway
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VEGF signaling pathway
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Gap junction
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Signaling pathways regulating pluripotency of stem cells
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T cell receptor signaling pathway
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B cell receptor signaling pathway
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Fc epsilon RI signaling pathway
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Fc gamma R-mediated phagocytosis
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GnRH signaling pathway
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Estrogen signaling pathway
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Melanogenesis
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Prolactin signaling pathway
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Thyroid hormone signaling pathway
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Oxytocin signaling pathway
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Tuberculosis
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Hepatitis B
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Influenza A
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MicroRNAs in cancer
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Non-small cell lung cancer
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Central carbon metabolism in cancer
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Choline metabolism in cancer
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NetPath Pathway
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IL-7 Signaling PathwayNetPath_17:IL5 Signaling Pathway
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IL2 Signaling Pathway
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EGFR1 Signaling Pathway
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PANTHER Pathway
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Angiogenesis
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Integrin signalling pathway
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Interleukin signaling pathway
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PDGF signaling pathway
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T cell activation
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VEGF signaling pathway
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Ras Pathway
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CCKR signaling map STP00005:Angiogenesis
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B cell activation
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EGF receptor signaling pathway
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Endothelin signaling pathway
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FGF signaling pathway
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Inflammation mediated by chemokine and cytokine signaling pathway
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Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
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Angiotensin II-stimulated signaling through G proteins and beta-arrestin
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CCKR signaling map ST
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Pathway Interaction Database
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CDC42 signaling events
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mTOR signaling pathway
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Ras signaling in the CD4+ TCR pathway
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ErbB1 downstream signaling
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PDGFR-beta signaling pathway
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Signaling events mediated by VEGFR1 and VEGFR2
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Trk receptor signaling mediated by the MAPK pathwayfcer1pathway:Fc-epsilon receptor I signaling in mast cells
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Endothelins
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BCR signaling pathway
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GMCSF-mediated signaling events
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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SHP2 signaling
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IL2-mediated signaling events
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IGF1 pathway
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Ceramide signaling pathway
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ErbB2/ErbB3 signaling events
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p38 signaling mediated by MAPKAP kinases
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Nongenotropic Androgen signaling
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Internalization of ErbB1
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CXCR3-mediated signaling events
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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Class I PI3K signaling events mediated by Akt
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Trk receptor signaling mediated by the MAPK pathway
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Downstream signaling in naï
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Regulation of retinoblastoma protein
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Signaling events mediated by focal adhesion kinase
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PathWhiz Pathway
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Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
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Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000453:Fc Epsilon Receptor I Signaling in Mast Cells
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Insulin Signalling
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Reactome
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Spry regulation of FGF signaling
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Frs2-mediated activation
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ARMS-mediated activation
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CREB phosphorylation through the activation of Ras
|
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RAF activation
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MAP2K and MAPK activation
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Negative feedback regulation of MAPK pathway
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Negative regulation of MAPK pathwayR-HSA-2672351:Stimuli-sensing channels
|
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GP1b-IX-V activation signalling
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CD209 (DC-SIGN) signaling
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Negative regulation of MAPK pathway
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WikiPathways
|
Serotonin Receptor 4/6/7 and NR3C Signaling
|
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Serotonin HTR1 Group and FOS Pathway
|
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Senescence and Autophagy in Cancer
|
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Regulation of Actin Cytoskeleton
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EGF/EGFR Signaling Pathway
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MAPK Cascade
|
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MAPK Signaling Pathway
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Bladder Cancer
|
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Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
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Polycystic Kidney Disease Pathway
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Corticotropin-releasing hormone
|
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B Cell Receptor Signaling Pathway
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Signaling Pathways in Glioblastoma
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Integrated Breast Cancer Pathway
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Signaling by FGFR
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NGF signalling via TRKA from the plasma membrane
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Integrin-mediated Cell AdhesionWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
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TCR Signaling Pathway
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EPO Receptor Signaling
|
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IL-2 Signaling Pathway
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Insulin Signaling
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TGF beta Signaling Pathway
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Signaling of Hepatocyte Growth Factor Receptor
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Kit receptor signaling pathway
|
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Extracellular vesicle-mediated signaling in recipient cells
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IL-3 Signaling Pathway
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Cardiac Hypertrophic Response
|
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RAF/MAP kinase cascade
|
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Iron uptake and transport
|
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Nanoparticle-mediated activation of receptor signaling
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PDGF Pathway
|
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Retinoblastoma (RB) in Cancer
|
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BDNF signaling pathway
|
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Integrated Pancreatic Cancer Pathway
|
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Oncostatin M Signaling Pathway
|
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Interleukin-11 Signaling Pathway
|
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AGE/RAGE pathway
|
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TNF alpha Signaling Pathway
|
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Prostate Cancer
|
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Endothelin Pathways
|
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TWEAK Signaling Pathway
|
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FSH signaling pathway
|
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Leptin signaling pathway
|
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Rap1 signalling
|
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Integrin-mediated Cell Adhesion
|
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GP1b-IX-V activation signalling
|
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MicroRNAs in cardiomyocyte hypertrophy
|
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IL-5 Signaling Pathway
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1943). |
|---|
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2184). |
|---|
