Drug Information

Drug General Information
Drug ID
D06XKX
Former ID
DNC014094
Drug Name
N-Propyl-2-phenylnorapomorphine hydrochloride
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530150]
Structure
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2D MOL

3D MOL
Formula
C25H26ClNO2
Canonical SMILES
CCCN1CCC2=CC(=CC3=C2C1CC4=C3C(=C(C=C4)O)O)C5=CC=CC=C5.C<br />l
InChI
1S/C25H25NO2.ClH/c1-2-11-26-12-10-18-13-19(16-6-4-3-5-7-16)14-20-23(18)21(26)15-17-8-9-22(27)25(28)24(17)20;/h3-9,13-14,21,27-28H,2,10-12,15H2,1H3;1H/t21-;/m1./s1
InChIKey
KUBBPURRDHRXFJ-ZMBIFBSDSA-N
PubChem Compound ID
45269973
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Inhibitor [530150]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 530150Bioorg Med Chem. 2009 Jul 1;17(13):4756-62. Epub 2009 May 3.N-Substituted-2-alkyl- and 2-arylnorapomorphines: novel, highly active D2 agonists.
Ref 530150Bioorg Med Chem. 2009 Jul 1;17(13):4756-62. Epub 2009 May 3.N-Substituted-2-alkyl- and 2-arylnorapomorphines: novel, highly active D2 agonists.

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