Drug General Information
Drug ID	D06WQT
Former ID	DIB011897
Drug Name	Nolatrexed
Synonyms	Thymitaq; AG-337; ZX-337; Nolatrexed (intravenous), EXIMIAS
Drug Type	Small molecular drug
Indication	Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48]		Phase 3	[521484]
Company	Agouron Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Formula	C14H12N4OS
Canonical SMILES	c1(=O)c2c(Sc3ccncc3)c(ccc2nc([nH]1)N)C.Cl.Cl
PubChem Compound ID	108189
Target and Pathway
Target(s)	Thymidylate synthase	Target Info	Inhibitor	[525434]
BioCyc Pathway	Pyrimidine deoxyribonucleotides biosynthesis from CTP
	Pyrimidine deoxyribonucleotides de novo biosynthesis
	Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
	Superpathway of pyrimidine deoxyribonucleoside salvage
	DTMP de novo biosynthesis (mitochondrial)
	Pyrimidine deoxyribonucleosides salvage
KEGG Pathway	Pyrimidine metabolism
	One carbon pool by folate
	Metabolic pathways
PANTHER Pathway	De novo pyrimidine deoxyribonucleotide biosynthesis
	Formyltetrahydroformate biosynthesis
Pathway Interaction Database	E2F transcription factor network
PathWhiz Pathway	Pyrimidine Metabolism
Reactome	E2F mediated regulation of DNA replication
	Pyrimidine biosynthesis
	G1/S-Specific Transcription
WikiPathways	Trans-sulfuration and one carbon metabolism
	Retinoblastoma (RB) in Cancer
	One Carbon Metabolism
	Integrated Pancreatic Cancer Pathway
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in leukocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	Metabolism of nucleotides
	Fluoropyrimidine Activity
References
Ref 521484	ClinicalTrials.gov (NCT00012324) Nolatrexed Dihydrochloride Compared With Doxorubicin in Treating Patients With Recurrent or Unresectable Liver Cancer. U.S. National Institutes of Health.
Ref 525434	A phase I study of the lipophilic thymidylate synthase inhibitor Thymitaq (nolatrexed dihydrochloride) given by 10-day oral administration. Br J Cancer. 1999 Feb;79(5-6):915-20.

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