Drug Information

Drug General Information
Drug ID
D06WAL
Former ID
DNC014906
Drug Name
Phlorizin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467998]
Structure
Download
2D MOL

3D MOL
Formula
C21H24O10
InChI
InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
InChIKey
IOUVKUPGCMBWBT-QNDFHXLGSA-N
PubChem Compound ID
6072
PubChem Substance ID
4758, 604347, 841199, 8153792, 11341596, 11361779, 11364185, 11366747, 11369309, 11372273, 11375279, 11377471, 11484617, 11487181, 11488517, 11491042, 11493465, 11495105, 11537644, 12159198, 14832537, 24398223, 25650095, 26613295, 26680738, 26754204, 29204476, 29585219, 47276655, 48394943, 49688949, 50023990, 50109810, 52203260, 53786912, 57323165, 85789298, 87550962, 87574490, 90469713, 92309306, 103529445, 104253598, 104311037, 124557462, 124558751, 124636196, 124757739, 125164543, 126617297
Target and Pathway
Target(s) Sodium/glucose cotransporter 1 Target Info Inhibitor [533444]
KEGG Pathway Carbohydrate digestion and absorption
Bile secretion
Mineral absorption
PathWhiz Pathway Lactose Degradation
Trehalose Degradation
Reactome Hexose transport
Na+-dependent glucose transporters
Inositol transporters
WikiPathways NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Metabolism of carbohydrates
References
Ref 467998(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4757).
Ref 533444J Biol Chem. 1988 Jan 5;263(1):187-92.High affinity phlorizin binding to the LLC-PK1 cells exhibits a sodium:phlorizin stoichiometry of 2:1.

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