Drug General Information
Drug ID
D06UDO
Former ID
DAP001073
Drug Name
Phenindamine
Synonyms
Fenindamina; Phenindaminum; Phenindiamine; Thephorin; NU 1504; Fenindamina [INN-Spanish]; Nolahist (TN); Phenindamine (INN); Phenindamine [INN:BAN]; Phenindaminum [INN-Latin]; Thephorin (TN); 2,3,4,9-Tetrahydro-2-methyl-9-phenyl-1H-indeno(2,1-c)pyridine; 2,3,4,9-Tetrahydro-2-methyl-9-phenyl-lH-indeno(2,1-c)pyridine; 2,3,4,9-tetrahydro-2-methyl-9-phenyl-lH-indeno-(2,1-c)pyridine; 2-Methyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1-c]pyridine; 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine
Drug Type
Small molecular drug
Indication Common cold; Allergies [ICD9: 460, 995.3; ICD10:J00, T78.4] Approved [550767]
Therapeutic Class
Antihistamines
Company
Amarin Pharmaceuticals
Structure
Download
2D MOL

3D MOL

Formula
C19H19N
Canonical SMILES
CN1CCC2=C(C1)C(C3=CC=CC=C23)C4=CC=CC=C4
InChI
1S/C19H19N/c1-20-12-11-16-15-9-5-6-10-17(15)19(18(16)13-20)14-7-3-2-4-8-14/h2-10,19H,11-13H2,1H3
InChIKey
ISFHAYSTHMVOJR-UHFFFAOYSA-N
CAS Number
CAS 82-88-2
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
R06AX04
SuperDrug CAS ID
cas=000082882
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [537846]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 550767Drug information of Phenindamine, 2008. eduDrugs.
Ref 537846The histamine H1-receptor antagonist binding site. A stereoselective pharmacophoric model based upon (semi-)rigid H1-antagonists and including a known interaction site on the receptor. J Med Chem. 1995 Aug 18;38(17):3351-60.

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