Drug Information

Drug General Information
Drug ID
D06QRP
Former ID
DIB019647
Drug Name
CP-481,715
Synonyms
CP481715; CP 481715; CP-481715
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540435]
Structure
Download
2D MOL
Formula
C26H31FN4O4
InChI
InChI=1S/C26H31FN4O4/c1-26(2,35)11-10-17(24(28)33)14-23(32)21(13-16-6-5-7-18(27)12-16)31-25(34)22-15-29-19-8-3-4-9-20(19)30-22/h3-9,12,15,17,21,23,32,35H,10-11,13-14H2,1-2H3,(H2,28,33)(H,31,34)/t17-,21+,23+/m1/s1
InChIKey
YEQJVHQCUDMXFG-FHZYATBESA-N
PubChem Compound ID
5311123
PubChem Substance ID
7979410, 11056284, 14834859, 14908047, 76143484, 114155322, 124958724, 129784903, 135253186, 143106829, 162814657, 163347362, 178100485, 198952256, 223871260, 227250336
Target and Pathway
Target(s) CC chemokine receptor Target Info Antagonist [526688]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Reactome Beta defensins
Binding and entry of HIV virion
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 540435(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3497).
Ref 526688CP-481,715, a potent and selective CCR1 antagonist with potential therapeutic implications for inflammatory diseases. J Biol Chem. 2003 Oct 17;278(42):40473-80. Epub 2003 Aug 7.

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