Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06QKW
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| Former ID |
DIB019143
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| Drug Name |
cirazoline
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C13H16N2O
|
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| InChI |
InChI=1S/C13H16N2O/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13/h1-4,10H,5-9H2,(H,14,15)
|
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| InChIKey |
YAORIDZYZDUZCM-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
4816529, 7978952, 8151786, 11110893, 11113761, 11120292, 11120780, 11121268, 11121651, 11122131, 11362720, 11365282, 11367844, 11370711, 11370712, 11373445, 11376006, 12012735, 14993968, 26751944, 26751945, 29221920, 47364966, 47440014, 48334242, 49979380, 50104620, 50104621, 50891172, 57321445, 85209513, 85788752, 90341611, 92098522, 92308777, 92310002, 99300914, 99302434, 103175726, 103936642, 104171120, 104301544, 124749647, 124879511, 124879512, 124879513, 124879514, 124879515, 129767852, 135027726
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| Target and Pathway | |||||
| Target(s) | Alpha-2C adrenergic receptor | Target Info | Agonist | [2] | |
| KEGG Pathway | cGMP-PKG signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| PANTHER Pathway | Alpha adrenergic receptor signaling pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Reactome | Adrenoceptors | ||||
| Adrenaline signalling through Alpha-2 adrenergic receptor | |||||
| Adrenaline,noradrenaline inhibits insulin secretion | |||||
| G alpha (i) signalling events | |||||
| G alpha (z) signalling events | |||||
| Surfactant metabolism | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Platelet Aggregation (Plug Formation) | |||||
| Integration of energy metabolism | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 515). | ||||
| REF 2 | Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36. | ||||
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