Drug Information

Drug General Information
Drug ID
D06PJW
Former ID
DIB019946
Drug Name
GSK-1838705A
Synonyms
GSK 1838705A; GSK1838705A
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530446]
Structure
Download
2D MOL
Formula
C27H29FN8O3
InChI
InChI=1S/C27H29FN8O3/c1-29-26(38)23-17(28)6-5-7-18(23)31-25-16-8-10-30-24(16)33-27(34-25)32-19-13-20-15(12-21(19)39-4)9-11-36(20)22(37)14-35(2)3/h5-8,10,12-13H,9,11,14H2,1-4H3,(H,29,38)(H3,30,31,32,33,34)
InChIKey
HZTYDQRUAWIZRE-UHFFFAOYSA-N
PubChem Compound ID
25182616
PubChem Substance ID
57290284, 57560329, 85028021, 103629211, 136348846, 136349563, 136367694, 141017575, 144116027, 152258421, 160647257, 162011614, 162038108, 162202695, 174006568, 174526213, 178102310, 180408479, 185990476, 189622850, 223705044, 224416783, 228335086, 237498825, 241377333, 242059764, 245173602, 247813672, 251963084, 252158607, 252160876, 252215504, 252443407, 252451201, 252671615
Target and Pathway
Target(s) ribosomal protein S6 kinase, 90kDa, polypeptide 1 Target Info Inhibitor [530446]
Insulin receptor Target Info Inhibitor [530446]
ALK tyrosine kinase receptor Target Info Inhibitor [530446]
mRNA of Insulin-like growth factor 1 receptor Target Info Inhibitor [531679]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Adherens junction
Insulin signaling pathway
Ovarian steroidogenesis
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorptionhsa05223:Non-small cell lung cancerhsa04014:Ras signaling pathway
Oocyte meiosis
Endocytosis
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Long-term depression
Progesterone-mediated oocyte maturation
Pathways in cancer
Transcriptional misregulation in cancer
Proteoglycans in cancer
Glioma
Prostate cancer
Melanoma
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Insulin/IGF pathway-protein kinase B signaling cascade
PI3 kinase pathwayP00032:Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Pathway Interaction Database Insulin Pathway
Signaling events mediated by PTP1B
Signaling events mediated by TCPTP
Insulin-mediated glucose transporter_nongenomic_pathway:Plasma membrane estrogen receptor signaling
SHP2 signaling
IGF1 pathway
Posttranslational regulation of adherens junction stability and dissassembly
Integrins in angiogenesis
Stabilization and expansion of the E-cadherin adherens junction
PathWhiz Pathway Insulin Signalling
Leucine Stimulation on Insulin Signaling
Reactome IRS activation
Signal attenuation
Insulin receptor signalling cascade
Insulin receptor recyclingR-HSA-2428928:IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1R
WikiPathways DNA Damage Response (only ATM dependent)
Insulin Signaling
Nanoparticle triggered autophagic cell death
AGE/RAGE pathway
Signaling by Insulin receptor
Folate Metabolism
Type II diabetes mellitus
Vitamin B12 Metabolism
Selenium Micronutrient Network
AMPK SignalingWP2848:Differentiation PathwayWP615:Senescence and Autophagy in Cancer
Endochondral Ossification
Focal Adhesion
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Apoptosis
Signaling Pathways in Glioblastoma
TSH signaling pathway
MicroRNAs in cardiomyocyte hypertrophy
References
Ref 530446GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers. Mol Cancer Ther. 2009 Oct;8(10):2811-20.
Ref 530446GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers. Mol Cancer Ther. 2009 Oct;8(10):2811-20.
Ref 531679Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol. 2011 Oct 30;29(11):1046-51.

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