Drug Information

Drug General Information
Drug ID
D06OVX
Former ID
DIB018536
Drug Name
25-hydroxycholesterol
Synonyms
25-OHC
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539911]
Structure
Download
2D MOL
Formula
C27H46O2
InChI
InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1
InChIKey
INBGSXNNRGWLJU-ZHHJOTBYSA-N
PubChem Compound ID
65094
PubChem Substance ID
629188, 7850677, 7888091, 8025559, 8189506, 14781420, 17396511, 26697233, 43121934, 46506794, 49688257, 50125921, 53790556, 57288449, 57288687, 57315308, 57390573, 78391031, 81087183, 87550999, 89649910, 103428966, 104332860, 126691998, 128191611, 135022176, 135651392, 137026010, 144206343, 160967689, 162814985, 172829377, 179317056, 184573804, 198989052, 223664194, 223720460, 224144613, 226538331, 241043524, 249925282
Target and Pathway
Target(s) RAR-related orphan receptor-gamma Target Info Agonist [530769]
GPR183 Target Info Agonist [531581]
References
Ref 539911(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2885).
Ref 530769Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma. Mol Endocrinol. 2010 May;24(5):923-9.
Ref 531581Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23.

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