Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06MQM
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| Former ID |
DAP001491
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| Drug Name |
Lumefantrine
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| Synonyms |
Benflumetol; Coartem; Dl-Benflumelol; Lumefantrine (INN); Lumefantrine [INN:BAN]; (+-)-2,7-Dichloro-9-((Z)-p-chlorobenzylidene)-alpha((dibutylamino)methyl)fluorene-4-methanol; (+-)-2,7-Dichloro-9-((Z)-p-chlorobenzylidene)-alpha-((dibutylamino)methyl)fluorene-4-methanol; 2-(dibutylamino)-1-[(9Z)-2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl]ethanol; 2-(dibutylamino)-1-[(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]fluoren-4-yl]ethanol; 2-Dibutylamino-1-[2,7-dichloro-9-(4-chloro-benzylidene)-9H-fluoren-4-yl]-ethanol; 2-Dibutylamino-1-{2,7-dichloro-9-[1-(4-chloro-phenyl)-meth-(Z)-ylidene]-9H-fluoren-4-yl}-ethanol
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| Drug Type |
Small molecular drug
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| Indication | Malaria [ICD10:B54] | Approved | [551871] | ||
| Structure |
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Download2D MOL |
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| Formula |
C30H32Cl3NO
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| Canonical SMILES |
CCCCN(CCCC)CC(C1=C2C3=C(C=C(C=C3)Cl)C(=CC4=CC=C(C=C4)Cl<br />)C2=CC(=C1)Cl)O
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| InChI |
1S/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3/b25-15-
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| InChIKey |
DYLGFOYVTXJFJP-MYYYXRDXSA-N
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| CAS Number |
CAS 82186-77-4
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| PubChem Compound ID | |||||
| PubChem Substance ID |
11967754, 14885370, 43030476, 47205892, 50065264, 50112743, 57367877, 75869758, 81092876, 85352679, 92720559, 93620655, 99007025, 99443260, 103215332, 114553360, 121360926, 126619887, 126647975, 126666837, 131327225, 131332294, 134222610, 135065105, 135684152, 136375542, 136949638, 137249473, 144206044, 152057600, 160967877, 162170615, 163656731, 164825530, 170465388, 172090904, 173896963, 174477484, 174530872, 175612331, 176235915, 179148062, 179322661, 180372451, 184017215, 184548301, 185974013, 187072118, 196111343, 198991533
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| Target and Pathway | |||||
| Target(s) | Sodium/potassium-transporting ATPase alpha-1 chain | Target Info | Binder | [536602] | |
| KEGG Pathway | cGMP-PKG signaling pathway | ||||
| cAMP signaling pathway | |||||
| Cardiac muscle contraction | |||||
| Adrenergic signaling in cardiomyocytes | |||||
| Insulin secretion | |||||
| Thyroid hormone synthesis | |||||
| Thyroid hormone signaling pathway | |||||
| Aldosterone-regulated sodium reabsorption | |||||
| Endocrine and other factor-regulated calcium reabsorption | |||||
| Proximal tubule bicarbonate reclamation | |||||
| Salivary secretion | |||||
| Gastric acid secretion | |||||
| Pancreatic secretion | |||||
| Carbohydrate digestion and absorption | |||||
| Protein digestion and absorption | |||||
| Bile secretion | |||||
| Mineral absorption | |||||
| Reactome | Ion transport by P-type ATPases | ||||
| WikiPathways | Iron uptake and transport | ||||
| References | |||||
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