Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06KYN
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| Former ID |
DAP000936
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| Drug Name |
Arbutamine
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| Synonyms |
Arbutamina; Arbutaminum; Genesa; Arbutamina [INN-Spanish]; Arbutamine [INN:BAN]; Arbutaminum [INN-Latin]; 4-[(1R)-1-hydroxy-2-[4-(4-hydroxyphenyl)butylamino]ethyl]benzene-1,2-diol; 4-[(1R)-1-hydroxy-2-{[4-(4-hydroxyphenyl)butyl]amino}ethyl]benzene-1,2-diol; 4-[1-hydroxy-2-[4-(4-hydroxyphenyl)butylamino]ethyl]benzene-1,2-diol
|
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| Drug Type |
Small molecular drug
|
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| Indication | Coronary artery disease [ICD9: 410-414, 429.2; ICD10:I20-I25] | Approved | [1] | ||
| Therapeutic Class |
Cardiotonic Agents
|
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| Structure |
|
Download2D MOL |
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| Formula |
C18H23NO4
|
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| Canonical SMILES |
C1=CC(=CC=C1CCCCNCC(C2=CC(=C(C=C2)O)O)O)O
|
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| InChI |
1S/C18H23NO4/c20-15-7-4-13(5-8-15)3-1-2-10-19-12-18(23)14-6-9-16(21)17(22)11-14/h4-9,11,18-23H,1-3,10,12H2
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| InChIKey |
IIRWWTKISYTTBL-UHFFFAOYSA-N
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| CAS Number |
CAS 128470-16-6
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| ChEBI ID |
ChEBI:50580
|
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| SuperDrug ATC ID |
C01CA22
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| SuperDrug CAS ID |
cas=128470166
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| Target and Pathway | |||||
| Target(s) | Beta-1 adrenergic receptor | Target Info | Stimulator | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cGMP-PKG signaling pathway | |||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Endocytosis | |||||
| Adrenergic signaling in cardiomyocytes | |||||
| Gap junction | |||||
| Salivary secretion | |||||
| Dilated cardiomyopathy | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Beta1 adrenergic receptor signaling pathway | |||||
| PathWhiz Pathway | Muscle/Heart Contraction | ||||
| Reactome | Adrenoceptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| Calcium Regulation in the Cardiac Cell | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Endothelin Pathways | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Drug information of Arbutamine, 2008. eduDrugs. | ||||
| REF 2 | Characterization of the adrenergic activity of arbutamine, a novel agent for pharmacological stress testing. Cardiovasc Drugs Ther. 1996 Mar;10(1):39-47. | ||||
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