Drug Information

Drug General Information
Drug ID
D06JIN
Former ID
DIB019262
Drug Name
compound 16
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529760]
Formula
C24H23N5O2
InChI
InChI=1S/C24H23N5O2/c30-24-21-14-22(28-23(21)26-16-27-24)19-7-8-25-20(13-19)6-5-17-1-3-18(4-2-17)15-29-9-11-31-12-10-29/h1-8,13-14,16H,9-12,15H2,(H2,26,27,28,30)/b6-5+
InChIKey
AWZFCQRICMFIES-AATRIKPKSA-N
PubChem Compound ID
16119710
PubChem Substance ID
24766928, 40654069, 85148083, 103588737, 137687657, 224288410, 230076226, 249565858
Target and Pathway
Target(s) Hepatocyte growth factor receptor Target Info Inhibitor [529760]
MAPKAP kinase 2 Target Info Inhibitor [529760]
Aurora protein kinase Target Info Inhibitor [529760]
MAPKAPK5 Target Info Inhibitor [529760]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
Axon guidance
Focal adhesion
Adherens junction
Bacterial invasion of epithelial cells
Epithelial cell signaling in Helicobacter pylori infection
Malaria
Pathways in cancer
Transcriptional misregulation in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Melanoma
Central carbon metabolism in cancerhsa04010:MAPK signaling pathway
VEGF signaling pathway
Neurotrophin signaling pathway
Viral carcinogenesishsa04114:Oocyte meiosis
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Angiogenesis
Interleukin signaling pathway
PDGF signaling pathway
VEGF signaling pathway
Ras Pathway
p38 MAPK pathway
Pathway Interaction Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Arf6 signaling events
Signaling events mediated by TCPTP
Posttranslational regulation of adherens junction stability and dissassembly
Direct p53 effectors
Syndecan-1-mediated signaling events
Stabilization and expansion of the E-cadherin adherens junction
a6b1 and a6b4 Integrin signaling
FGF signaling pathway
Regulation of retinoblastoma proteinil2_1pathway:IL2-mediated signaling events
p38 signaling mediated by MAPKAP kinases
Signaling mediated by p38-alpha and p38-beta
Signaling events mediated by VEGFR1 and VEGFR2
Trk receptor signaling mediated by the MAPK pathwayp38alphabetadownstreampathway:Signaling mediated by p38-alpha and p38-beta
Reactome Sema4D mediated inhibition of cell attachment and migrationR-HSA-171007:p38MAPK events
Oxidative Stress Induced Senescence
Regulation of HSF1-mediated heat shock response
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activationR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate ForminsR-HSA-2559580:Oxidative Stress Induced Senescence
MAPK6/MAPK4 signaling
WikiPathways TGF beta Signaling Pathway
Signaling of Hepatocyte Growth Factor Receptor
Focal Adhesion
Extracellular vesicle-mediated signaling in recipient cells
Signaling Pathways in Glioblastoma
miR-targeted genes in squamous cell - TarBase
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
Semaphorin interactionsWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Serotonin HTR1 Group and FOS Pathway
p38 MAPK Signaling Pathway
MAPK Signaling Pathway
FAS pathway and Stress induction of HSP regulation
MAP kinase activation in TLR cascade
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
Arachidonic acid metabolism
Structural Pathway of Interleukin 1 (IL-1)
Regulation of Microtubule Cytoskeleton
IL-1 signaling pathway
NGF signalling via TRKA from the plasma membrane
MAPK targets/ Nuclear events mediated by MAP kinasesWP437:EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP400:p38 MAPK Signaling Pathway
References
Ref 529760Pyrrolo-pyrimidones: a novel class of MK2 inhibitors with potent cellular activity. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6142-6.
Ref 529760Pyrrolo-pyrimidones: a novel class of MK2 inhibitors with potent cellular activity. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6142-6.

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