Drug Information

Drug General Information
Drug ID
D06GFZ
Former ID
DIB018972
Drug Name
BIIE0246
Synonyms
BIIE 0246; BIIE-0246
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538946]
Structure
Download
2D MOL
Formula
C49H57N11O6
InChI
InChI=1S/C49H57N11O6/c50-46(51)53-25-13-22-40(45(64)52-26-27-58-47(65)59(34-14-3-1-4-15-34)60(48(58)66)35-16-5-2-6-17-35)54-41(61)32-49(23-11-12-24-49)33-42(62)56-28-30-57(31-29-56)43-36-18-7-8-19-37(36)44(63)55-39-21-10-9-20-38(39)43/h1-10,14-21,40,43H,11-13,22-33H2,(H,52,64)(H,54,61)(H,55,63)(H4,50,51,53)/t40-,43?/m0/s1
InChIKey
RSJAXPUYVJKAAA-JPGJPTAESA-N
PubChem Compound ID
9811493
PubChem Substance ID
14767448, 14841039, 26753176, 44847477, 49684207, 49958863, 51220160, 57373394, 91746263, 103689709, 104136848, 134222956, 135649994, 144240328, 144240329, 162220492, 163124351, 172649804, 172913000, 204379276, 241375585, 252156046
Target and Pathway
Target(s) Neuropeptide Y receptor type 2 Target Info Antagonist [526081]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 538946(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1547).
Ref 526081The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning. Mol Pharmacol. 2001 Jul;60(1):124-34.

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