Drug General Information
Drug ID
D06FDR
Former ID
DAP000702
Drug Name
Didanosine
Synonyms
DDI; DIDEOXYINOSINE; DdIno; Didanosina; Didanosinum; Videx; Hypoxanthine ddN; Videx EC; BMY 40900; BMY-40900; DRG-0016; DdI + d4T combination; Didanosina [INN-Spanish]; Didanosinum [INN-Latin]; Dideoxyinosine (DDI); Intron A & Videx; KS-1049; LOA & ddI; Videx (TN); Videx EC (TN); Videx(TM); DDI and rIFN.alpha.2; DS-4152 & ddI; DdI & GM-CSF; DdI & IFN-alpha; DdI & sCD4(rsCD4); PC-SOD+ddI; Didanosine (JAN/USAN/INN); Videx EC(TM)(slow-release capsules); Didanosine and Interferon-.alpha.-2; Listera ovata agglutinin & 2',3'-Dideoxyinosine; Sulfated polysaccharide-peptidoglycan DS-4152 & 2',3'-Dideoxyinosine; Inosine, 2',3'-dideoxy-& Recombinant Interferon-.alpha.-2; 2',3'-Dideoxyinosine; 2',3'-Dideoxyinosine & Granulocyte-macrophage colony-stimulating factor; 2',3'-Dideoxyinosine & Interferon-alpha; 2',3'-Dideoxyinosine & sCD4(soluble recombinant protein); 2',3'-Dideoxyinosine (AIDS Initiative); 2',3'-Dideoxyinosine (ddI); 2',3'-dideoxyinosine, DDI, NSC 612049, Didanosine; 2'3'-DIDEOXYINOSINE; 2,3-dideoxyinosine; 3'-Azido-3'-deoxythymidine + 2',3'-Dideoxyinosine; 9-((2R,5S)-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one; 9-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one; 9-(2,3-Dideoxy-beta-D-ribofuranosyl)-6-oxopurine; 9-(2,3-Dideoxy-beta-D-ribofuranosyl)hypoxanthine; 9-[(2R,5R)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL]-1,9-DIHYDRO-6H-PURIN-6-ONE; 9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one; 9-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one; DDI
Drug Type
Small molecular drug
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Approved [468066], [536361]
Therapeutic Class
Anti-HIV Agents
Company
Bristol-Myers Squibb
Structure
Download
2D MOL

3D MOL

Formula
C10H12N4O3
InChI
InChI=1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7,15H,1-3H2,(H,11,12,16)/t6-,7+/m0/s1
InChIKey
BXZVVICBKDXVGW-NKWVEPMBSA-N
CAS Number
CAS 69655-05-6
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
J05AF02
SuperDrug CAS ID
cas=069655056
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) HIV reverse transcriptase Target Info Inhibitor [537278]
References
Ref 468066(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4833).
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 537278The effect of individual antiretroviral drugs on body composition in HIV-infected persons initiating highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2009 Jul 1;51(3):298-304.

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