TTD | Drug: D06EES

Drug General Information
Drug ID	D06EES
Former ID	DNC012475
Drug Name	Leucine-enkephalin
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533377]
Structure		Download 2D MOL 3D MOL
Formula	C28H37N5O7
Canonical SMILES	CC(C)CC(C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O<br />)C(CC2=CC=C(C=C2)O)N
InChI	1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)
InChIKey	URLZCHNOLZSCCA-UHFFFAOYSA-N
PubChem Compound ID	3903
Target and Pathway
Target(s)	Mu-type opioid receptor	Target Info	Inhibitor	[533377]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Estrogen signaling pathway
	Morphine addiction
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Enkephalin release
Pathway Interaction Database	IL4-mediated signaling events
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (i) signalling events
WikiPathways	TCR Signaling Pathway
	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	Opioid Signalling
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 533377	J Med Chem. 1986 Jul;29(7):1222-5.Peptides as receptor selectivity modulators of opiate pharmacophores.
Ref 533377	J Med Chem. 1986 Jul;29(7):1222-5.Peptides as receptor selectivity modulators of opiate pharmacophores.

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Drug Information