Drug Information

Drug General Information
Drug ID
D06CXG
Former ID
DNC011589
Drug Name
PD-135540
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551251]
Structure
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2D MOL

3D MOL
Formula
C22H28N4
Canonical SMILES
C1CC(=CCC1CCN2CCN(CC2)C3=CC=CC=N3)C4=CC=CC=N4
InChI
1S/C22H28N4/c1-3-12-23-21(5-1)20-9-7-19(8-10-20)11-14-25-15-17-26(18-16-25)22-6-2-4-13-24-22/h1-6,9,12-13,19H,7-8,10-11,14-18H2
InChIKey
KTGXACIWWLVCPX-UHFFFAOYSA-N
PubChem Compound ID
15079633
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Inhibitor [551251]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 551251Synthesis and pharmacological evaluation of the enantiomers of the dopamine autoreceptor agonist PD 135385, Bioorg. Med. Chem. Lett. 3(4):639-644 (1993).
Ref 551251Synthesis and pharmacological evaluation of the enantiomers of the dopamine autoreceptor agonist PD 135385, Bioorg. Med. Chem. Lett. 3(4):639-644 (1993).

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