Drug Information

Drug General Information
Drug ID
D06CMG
Former ID
DIB020205
Drug Name
LDN-214117
Synonyms
compound 10 [PMID: 25101911]
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532556]
Structure
Download
2D MOL
Formula
C25H29N3O3
InChI
InChI=1S/C25H29N3O3/c1-17-22(19-14-23(29-2)25(31-4)24(15-19)30-3)13-20(16-27-17)18-5-7-21(8-6-18)28-11-9-26-10-12-28/h5-8,13-16,26H,9-12H2,1-4H3
InChIKey
BHUXVRVMMYAXKN-UHFFFAOYSA-N
PubChem Compound ID
91754554
PubChem Substance ID
250184700, 252166689, 252451411, 252479330
Target and Pathway
Target(s) TGF-beta receptor type I Target Info Inhibitor [532914]
activin A receptor, type I Target Info Inhibitor [532914]
Activin receptor-like kinase-1 Target Info Inhibitor [532914]
Bone morphogenetic protein receptor Target Info Inhibitor [532914]
KEGG Pathway MAPK signaling pathway
Cytokine-cytokine receptor interaction
FoxO signaling pathway
Endocytosis
TGF-beta signaling pathway
Osteoclast differentiation
Hippo signaling pathway
Adherens junction
Chagas disease (American trypanosomiasis)
Hepatitis B
HTLV-I infection
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Chronic myeloid leukemiahsa04060:Cytokine-cytokine receptor interaction
Signaling pathways regulating pluripotency of stem cells
PANTHER Pathway TGF-beta signaling pathwayP00052:TGF-beta signaling pathway
Pathway Interaction Database Glypican 1 network
ALK1 signaling events
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
TGF-beta receptor signalingalk1_2pathway:ALK1 pathway
Reactome TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
WikiPathways TGF Beta Signaling Pathway
p38 MAPK Signaling Pathway
MAPK Signaling Pathway
TGF beta Signaling Pathway
Extracellular vesicle-mediated signaling in recipient cells
Cardiac Hypertrophic Response
Signaling by TGF-beta Receptor Complex
Integrated Pancreatic Cancer Pathway
Integrated Breast Cancer PathwayWP474:Endochondral Ossification
Ectoderm Differentiation
Mesodermal Commitment Pathway
Endoderm Differentiation
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Hair Follicle Development: Induction (Part 1 of 3)
Signaling by BMP
Integrated Breast Cancer Pathway
Heart Development
BMP Signalling and Regulation
References
Ref 532556ACVR1 (587T>C) mutation in a variant form of fibrodysplasia ossificans progressiva: second report. Am J Med Genet A. 2014 Jan;164A(1):220-4.
Ref 532914Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem. 2014 Oct 9;57(19):7900-15.

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