Drug Information

Drug General Information
Drug ID
D06AGD
Former ID
DIB002009
Drug Name
MK-0963
Synonyms
L-654066; MK-963; (5alpha)-23-Methyl-4-aza-21-norchol-1-ene-3,20-dione; 23-Methyl-21-nor-4-aza-5alpha-chol-1-ene-3,20-dione
Drug Type
Small molecular drug
Indication Prostate disease [ICD10:N42.9] Discontinued in Phase 1 [545468]
Structure
Download
2D MOL

3D MOL
Formula
C23H35NO2
Canonical SMILES
CC(C)CC(=O)C1CCC2C1(CCC3C2CCC4C3(C=CC(=O)N4)C)C
InChI
1S/C23H35NO2/c1-14(2)13-19(25)18-7-6-16-15-5-8-20-23(4,12-10-21(26)24-20)17(15)9-11-22(16,18)3/h10,12,14-18,20H,5-9,11,13H2,1-4H3,(H,24,26)
InChIKey
RDPJISLOFXUIDK-UHFFFAOYSA-N
CAS Number
CAS 103497-68-3
PubChem Compound ID
59758
PubChem Substance ID
43117258, 50271248, 103275283, 103935332, 104319004, 117566505
Target and Pathway
Target(s) 5-alpha reductase Target Info Inhibitor [533979], [551871]
References
Ref 545468Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003374)
Ref 533979Pharmacodynamics of MK-0963, a new 5 alpha-reductase inhibitor: effects on serum androgen concentrations. Clin Pharmacol Ther. 1994 Jan;55(1):50-4.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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