Drug General Information
Drug ID
D05YUI
Former ID
DIB000968
Drug Name
Ex vivo adenosine deaminase-transduced hematopoietic stem cell therapy
Synonyms
Adenosine deaminase-transduced hematopoietic stem cell therapy; Ex vivo adenosine deaminase-transduced hematopoietic stem cell therapy (ADA-SCID)
Indication Immunodeficiency [ICD9: 279.3; ICD10:D84.9] Phase 1/2 [551929]
Company
San Raffaele Telethon Institute for Gene Therapy
Target and Pathway
Target(s) Adenosine deaminase Target Info Modulator [551928]
BioCyc Pathway Purine nucleotides degradation
Purine deoxyribonucleosides degradation
Purine ribonucleosides degradation to ribose-1-phosphate
Adenosine nucleotides degradation
Superpathway of purine nucleotide salvage
Adenine and adenosine salvage III
KEGG Pathway Purine metabolism
Metabolic pathways
Primary immunodeficiency
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Adenine and hypoxanthine salvage pathway
Pathway Interaction Database p73 transcription factor network
C-MYB transcription factor network
Validated transcriptional targets of deltaNp63 isoforms
Validated transcriptional targets of TAp63 isoforms
PathWhiz Pathway Purine Metabolism
Reactome Purine salvage
WikiPathways Metabolism of nucleotides
References
Ref 551929Clinical pipeline report, company report or official report of GlaxoSmithKline.
Ref 551928Clinical pipeline report, company report or official report of GlaxoSmithKline.

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