Drug Information

Drug General Information
Drug ID
D05XZQ
Former ID
DIB007396
Drug Name
HepaStem
Indication Liver failure [ICD10:K72.9] Phase 2 [525254]
Company
Promethera Biosciences SA/NV
Target and Pathway
Target(s) Phenylalanine hydroxylase Target Info Modulator [543386]
BioCyc Pathway Phenylalanine degradation/tyrosine biosynthesis
KEGG Pathway Phenylalanine metabolism
Phenylalanine, tyrosine and tryptophan biosynthesis
Metabolic pathways
Biosynthesis of amino acids
PathWhiz Pathway Phenylalanine and Tyrosine Metabolism
WikiPathways SIDS Susceptibility Pathways
Biogenic Amine Synthesis
Metabolism of amino acids and derivatives
Abnormal metabolism in phenylketonuria
References
Ref 525254ClinicalTrials.gov (NCT02489292) Study to Evaluate the Efficacy of HepaStem in Urea Cycle Disorders Paediatric Patients (HEP002).
Ref 543386(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1240).

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