Drug General Information
Drug ID	D05WZL
Former ID	DNC014558
Drug Name	((E)-3-Amino-propenyl)-methyl-phosphinic acid
Synonyms	3-aminoprop-1-enyl(methyl)phosphinic acid
Indication	Discovery agent		Investigative	[529517]
Structure		Download 2D MOL 3D MOL
Canonical SMILES	CP(=O)(C=CCN)O
InChI	1S/C4H10NO2P/c1-8(6,7)4-2-3-5/h2,4H,3,5H2,1H3,(H,6,7)/b4-2+
InChIKey	FZCMREWADROMJN-DUXPYHPUSA-N
Target and Pathway
Target(s)	Gamma-aminobutyric acid B receptor	Target Info	Inhibitor	[533678]
	Gamma-aminobutyric acid receptor	Target Info	Inhibitor	[529517]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	GABAergic synapse
	Estrogen signaling pathway
	Morphine addiction
Reactome	Activation of G protein gated Potassium channels
	G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways	GPCRs, Class C Metabotropic glutamate, pheromone
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Potassium Channels
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 529517	J Med Chem. 2008 Jul 10;51(13):3825-40. Epub 2008 Jun 5.Novel gamma-aminobutyric acid rho1 receptor antagonists; synthesis, pharmacological activity and structure-activity relationships.
Ref 529517	J Med Chem. 2008 Jul 10;51(13):3825-40. Epub 2008 Jun 5.Novel gamma-aminobutyric acid rho1 receptor antagonists; synthesis, pharmacological activity and structure-activity relationships.
Ref 533678	J Med Chem. 1995 Aug 18;38(17):3297-312.Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists.

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