Drug Information
Drug General Information | |||||
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Drug ID |
D05USL
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Former ID |
DNC007250
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Drug Name |
KU-55933
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Drug Type |
Small molecular drug
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Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Investigative | [541213] | ||
Structure |
Download2D MOL |
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Formula |
C21H17NO3S2
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InChI |
InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
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InChIKey |
XRKYMMUGXMWDAO-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID |
7844841, 8615301, 11114627, 11164641, 14781018, 26758160, 29203552, 39287686, 46391370, 46493711, 57357692, 75370431, 85083135, 98629299, 99302612, 99436975, 103511262, 104085576, 113847780, 117682509, 124756991, 125163796, 125503170, 126626060, 126658559, 126665902, 126729190, 131480676, 134344455, 134964017, 135272753, 135685400, 135685401, 135685420, 135686218, 135686219, 135686234, 135686235, 135698625, 136340184, 136367291, 136367904, 136920401, 137054921, 139118899, 143496651, 144116111, 152234890, 152258339, 152344221
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Target and Pathway | |||||
Target(s) | DNA-dependent protein kinase catalytic subunit | Target Info | Inhibitor | [528738] | |
KEGG Pathway | Non-homologous end-joining | ||||
Cell cycle | |||||
NetPath Pathway | IL1 Signaling Pathway | ||||
Reactome | Nonhomologous End-Joining (NHEJ) | ||||
References | |||||
Ref 528738 | J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase. |
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