Drug General Information
Drug ID	D05UOW
Former ID	DNC000542
Drug Name	DFMO
Drug Type	Small molecular drug
Indication	Discovery agent		Withdrawn from market	[545498]
Structure		Download 2D MOL 3D MOL
Formula	C6H15ClF2N2O3
Canonical SMILES	C(CC(C(F)F)(C(=O)O)N)CN.O.Cl
InChI	1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2
InChIKey	FJPAMFNRCFEGSD-UHFFFAOYSA-N
CAS Number	CAS 67037-37-0
PubChem Compound ID	441361
PubChem Substance ID	7847894, 10298810, 11528794, 12012626, 14847342, 26758603, 36885214, 57403653, 75862619, 85174277, 92721283, 103771020, 104625288, 118048823, 123392510, 125360341, 126619282, 131331440, 134339945, 135015827, 137045301, 162189306, 162228319, 163124492, 163688237, 176227366, 179685417, 204375137, 215781502, 223704632, 224835239, 225229710, 226396488, 241168103, 252348838
ChEBI ID	ChEBI:41948
SuperDrug ATC ID	P01CX03
SuperDrug CAS ID	cas=070052129
Target and Pathway
Target(s)	Ornithine decarboxylase	Target Info	Inhibitor	[534924]
BioCyc Pathway	Putrescine biosynthesis I
NetPath Pathway	TCR Signaling Pathway
	IL2 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Ornithine degradation
	CCKR signaling map ST
Pathway Interaction Database	Validated targets of C-MYC transcriptional activation
PathWhiz Pathway	Spermidine and Spermine Biosynthesis
References
Ref 545498	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003500)
Ref 534924	X-ray structure of ornithine decarboxylase from Trypanosoma brucei: the native structure and the structure in complex with alpha-difluoromethylornithine. Biochemistry. 1999 Nov 16;38(46):15174-84.

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