Drug General Information
Drug ID
D05UKK
Former ID
DIB001653
Drug Name
FK-888
Drug Type
Small molecular drug
Indication Migraine [ICD9: 346; ICD10:G43] Discontinued in Phase 2 [539339], [545042]
Company
Fujisawa Pharmaceutical Co Ltd
Structure
Download
2D MOL

3D MOL

Formula
C36H36N4O4
InChI
InChI=1S/C36H36N4O4/c1-38-23-30(29-14-8-9-15-32(29)38)35(43)40-22-28(41)20-33(40)34(42)37-31(36(44)39(2)21-24-10-4-3-5-11-24)19-25-16-17-26-12-6-7-13-27(26)18-25/h3-18,23,28,31,33,41H,19-22H2,1-2H3,(H,37,42)/t28-,31+,33+/m1/s1
InChIKey
BFNKQTIJVFGCKQ-PDJGWCFMSA-N
CAS Number
CAS 138449-07-7
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Substance-P receptor Target Info Antagonist [526652]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539339(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2114).
Ref 545042Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001953)
Ref 526652Pharmacological profile of a high affinity dipeptide NK1 receptor antagonist, FK888. Br J Pharmacol. 1992 Nov;107(3):785-9.

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