Drug Information

Drug General Information
Drug ID
D05UGC
Former ID
DIB020461
Drug Name
muramyl dipeptide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468133]
Structure
Download
2D MOL
Formula
C19H32N4O11
InChI
InChI=1S/C19H32N4O11/c1-7(17(30)23-10(16(20)29)4-5-12(26)27)21-18(31)8(2)33-15-13(22-9(3)25)19(32)34-11(6-24)14(15)28/h7-8,10-11,13-15,19,24,28,32H,4-6H2,1-3H3,(H2,20,29)(H,21,31)(H,22,25)(H,23,30)(H,26,27)/t7-,8+,10+,11+,13+,14+,15+,19+/m0/s1
InChIKey
BSOQXXWZTUDTEL-ZUYCGGNHSA-N
PubChem Compound ID
451714
PubChem Substance ID
596528, 596564, 24562485, 57405285, 76947167, 96079573, 103730353, 104644416, 135241510, 135935860, 137019948, 178101721, 226426755, 252824049
Target and Pathway
Target(s) NLRP1 Target Info Agonist [543480]
Pattern recognition receptor NOD2 Target Info Agonist [543479]
KEGG Pathway NOD-like receptor signaling pathway
TNF signaling pathway
Shigellosis
Tuberculosis
Inflammatory bowel disease (IBD)
Pathway Interaction Database Canonical NF-kappaB pathway
Reactome NOD1/2 Signaling Pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 signaling
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
WikiPathways MAP kinase activation in TLR cascade
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 signaling
NOD pathway
References
Ref 468133(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5024).
Ref 543479(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1763).
Ref 543480(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1768).

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