Drug Information

Drug General Information
Drug ID
D05TOJ
Former ID
DIB010843
Drug Name
Peretinoin
Synonyms
Polyprenoic acid; E-5166; NIK-333; Peretinoin (oral); Peretinoin (oral), Kowa; Peretinoin (oral formulation, hepatocellular carcinoma), Kowa Pharmaceutical
Drug Type
Small molecular drug
Indication Hepatocellular carcinoma [ICD9: 155; ICD10:C22.0] Phase 3 [523972]
Company
Kowa Pharmaceutical Co Ltd; Eisai Co Ltd
Structure
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2D MOL

3D MOL
Formula
C20H30O2
Canonical SMILES
C(=C(\C=C\C=C(\CC/C=C(/CCC=C(C)C)\C)/C)/C)/C(=O)O
CAS Number
CAS 81485-25-8
PubChem Compound ID
6437836
Target and Pathway
Target(s) Retinoic acid receptor Target Info Modulator [532310]
References
Ref 523972ClinicalTrials.gov (NCT01640808) Study of Peretinoin for Suppressing Recurrence of HCV-positive HCC. U.S. National Institutes of Health.
Ref 532310Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma. BMC Cancer. 2013 Apr 15;13:191.

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