Drug Information

Drug General Information
Drug ID
D05TNX
Former ID
DIB019863
Drug Name
fluprostenol
Synonyms
ICI 81008
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539240]
Structure
Download
2D MOL
Formula
C23H29F3O6
InChI
InChI=1S/C23H29F3O6/c24-23(25,26)15-6-5-7-17(12-15)32-14-16(27)10-11-19-18(20(28)13-21(19)29)8-3-1-2-4-9-22(30)31/h1,3,5-7,10-12,16,18-21,27-29H,2,4,8-9,13-14H2,(H,30,31)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m1/s1
InChIKey
WWSWYXNVCBLWNZ-QIZQQNKQSA-N
PubChem Compound ID
5311100
PubChem Substance ID
7979290, 11056269, 14833691, 14959572, 26754611, 29216067, 39340820, 47216547, 47810513, 50110093, 51060530, 53786902, 85787689, 92309752, 99300666, 99302184, 104046520, 104222381, 114155262, 124892256, 124963557, 135650277, 143054778, 144205331, 163884230, 164234741, 172648729, 175269771, 178100423, 179205558, 198983226, 224677454, 226582737, 241377045, 252158156, 252455476, 252457294, 252462915, 252467640
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Agonist [525673]
Prostaglandin E2 receptor EP3 subtype Target Info Agonist [525673]
Prostaglandin F2-alpha receptor Target Info Agonist [534478]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activationhsa04020:Calcium signaling pathway
cAMP signaling pathway
Regulation of lipolysis in adipocytes
Pathways in cancerhsa04020:Calcium signaling pathway
NetPath Pathway IL2 Signaling Pathway
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptorR-HSA-391908:Prostanoid ligand receptors
G alpha (i) signalling eventsR-HSA-391908:Prostanoid ligand receptors
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
GPCR downstream signaling
GPCRs, Other
References
Ref 539240(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1940).
Ref 525673The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93.
Ref 534478Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24.

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