Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05SNR
|
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| Former ID |
DNC006235
|
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| Drug Name |
5-(pentylthio)thiazolo[4,5-d]pyrimidin-7-ol
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C10H13N3OS2
|
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| Canonical SMILES |
CCCCCSC1=NC(=O)C2=C(N1)N=CS2
|
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| InChI |
1S/C10H13N3OS2/c1-2-3-4-5-15-10-12-8-7(9(14)13-10)16-6-11-8/h6H,2-5H2,1H3,(H,12,13,14)
|
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| InChIKey |
QONMYXCFINJDMT-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | High affinity interleukin-8 receptor B | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Cytokine-cytokine receptor interaction | ||||
| Chemokine signaling pathway | |||||
| Endocytosis | |||||
| Epithelial cell signaling in Helicobacter pylori infection | |||||
| NetPath Pathway | TNFalpha Signaling Pathway | ||||
| PANTHER Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | ||||
| Interleukin signaling pathway | |||||
| Pathway Interaction Database | IL8- and CXCR2-mediated signaling events | ||||
| Reactome | Chemokine receptors bind chemokines | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2006 Feb 15;16(4):960-3. Epub 2005 Nov 15.Hit-to-Lead studies: the discovery of potent, orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists. | ||||
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