TTD | Drug: D05SLM

Drug General Information
Drug ID	D05SLM
Former ID	DIB010099
Drug Name	LY-2590443
Indication	Migraine [ICD9: 346; ICD10:G43]		Phase 2	[522513]
Company	Eli Lilly & Co
Target and Pathway
Target(s)	Substance-P receptor	Target Info	Antagonist	[543792]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Measles
PANTHER Pathway	CCKR signaling map ST
Reactome	G alpha (q) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 522513	ClinicalTrials.gov (NCT00804973) Study in Subjects With Acute Migraines Headaches.. U.S. National Institutes of Health.
Ref 543792	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 360).

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Drug Information