Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05SFA
|
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| Former ID |
DIB019133
|
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| Drug Name |
cicaprost
|
||||
| Synonyms |
ZK 96480; ZK-96480
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [539218] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C22H30O5
|
||||
| InChI |
InChI=1S/C22H30O5/c1-3-4-5-6-15(2)20(23)8-7-18-19-12-16(9-10-27-14-22(25)26)11-17(19)13-21(18)24/h9,15,17-21,23-24H,3,6,10-14H2,1-2H3,(H,25,26)/b16-9+/t15-,17-,18+,19-,20+,21+/m0/s1
|
||||
| InChIKey |
ARUGKOZUKWAXDS-SEWALLKFSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Prostacyclin receptor | Target Info | Agonist | [534478] | |
| Prostaglandin E2 receptor, EP1 subtype | Target Info | Agonist | [525673] | ||
| Prostaglandin E2 receptor EP3 subtype | Target Info | Agonist | [534478] | ||
| Prostaglandin E2receptor, EP2 subtype | Target Info | Agonist | [534478] | ||
| Prostaglandin E2 receptor, EP4 subtype | Target Info | Agonist | [525673] | ||
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Vascular smooth muscle contraction | |||||
| Platelet activationhsa04020:Calcium signaling pathway | |||||
| Pathways in cancerhsa04020:Calcium signaling pathway | |||||
| cAMP signaling pathway | |||||
| Regulation of lipolysis in adipocytes | |||||
| Pathways in cancerhsa04024:cAMP signaling pathway | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| Renin secretion | |||||
| Pathways in cancerhsa04080:Neuroactive ligand-receptor interaction | |||||
| Pathways in cancer | |||||
| PANTHER Pathway | PI3 kinase pathway | ||||
| Pathway Interaction Database | Thromboxane A2 receptor signaling | ||||
| WikiPathways | Prostaglandin Synthesis and Regulation | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Small Ligand GPCRs | |||||
| Endothelin Pathways | |||||
| Platelet homeostasis | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Ovarian Infertility Genes | |||||
| Vitamin D Receptor Pathway | |||||
| GPCR downstream signaling | |||||
| References | |||||
| Ref 525673 | The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. | ||||
| Ref 534478 | Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. | ||||
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