Drug Information

Drug General Information
Drug ID
D05OQX
Former ID
DCL000892
Drug Name
NCX-4016
Synonyms
Nitroaspirin; Ncx 4016; NO-ASA; Nitric oxide-releasing aspirin; M-NO-ASA; M-NO-aspirin; [3-(nitrooxymethyl)phenyl] 2-acetyloxybenzoate; Benzoic acid, 2-(acetyloxy)-, 2-((nitrooxy)methyl)phenyl ester; Benzoic acid, 2-(acetyloxy)-, 3-((nitrooxy)methyl)phenyl ester; 2-((Nitrooxy)methyl)phenyl 2-(acetyloxy)benzoate; 2-Acetoxybenzoate-2-(1-nitroxymethyl)phenyl ester; 2-Acetoxybenzoic acid 3-(nitrooxymethyl)phenyl ester; 2-Acetoxybenzoic acid 3-nitrooxymethylphenyl ester; 3-((Nitrooxy)methyl)phenyl 2-(acetyloxy)benzoate; 3-(Nitroxymethyl)phenyl 2-acetoxybenzoate
Drug Type
Small molecular drug
Indication Inflammation [ICD10:E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89] Phase 2 [527729]
Type 2 diabetes; Early nephropathy; Claudication [ICD9: 250, 250.00, 250.02, 250.4, 338, 437.6, 443.9, 453, 580-599, 671.5, 671.9,780; ICD10:E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89] Discontinued in Phase 2 [536186]
Therapeutic Class
Analgesics
Company
NiCox SA
Structure
Download
2D MOL

3D MOL
Formula
C16H13NO7
Canonical SMILES
CC(=O)OC1=CC=CC=C1C(=O)OC2=CC=CC(=C2)CO[N+](=O)[O-]
InChI
1S/C16H13NO7/c1-11(18)23-15-8-3-2-7-14(15)16(19)24-13-6-4-5-12(9-13)10-22-17(20)21/h2-9H,10H2,1H3
InChIKey
IOJUJUOXKXMJNF-UHFFFAOYSA-N
CAS Number
CAS 175033-36-0
PubChem Compound ID
119032
PubChem Substance ID
10238310, 12015129, 14753203, 29300007, 49885484, 49885485, 57339286, 58107393, 76715522, 78150432, 103516115, 104407375, 125684073, 128197063, 134339344, 135075287, 135223452, 137267752, 140085480, 162803461, 164231370, 164763613, 175607686, 177749479, 204363032, 226409254, 252815212
Target and Pathway
Target(s) Cyclooxygenase Target Info Inhibitor [536186]
References
Ref 527729Direct and irreversible inhibition of cyclooxygenase-1 by nitroaspirin (NCX 4016). J Pharmacol Exp Ther. 2005 Dec;315(3):1331-7. Epub 2005 Sep 6.
Ref 536186Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90.
Ref 536186Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90.

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