Drug Information

Drug General Information
Drug ID
D05NJI
Former ID
DCL000238
Drug Name
STX 64
Synonyms
BN-83495; STX-64; (6-oxo-8,9,10,11-tetrahydro-7H-cyclohepta[c]chromen-3-yl) sulfamate; 6-OXO-8,9,10,11-TETRAHYDRO-7H-CYCLOHEPTA[C][1]BENZOPYRAN-3-O-SULFAMATE; 667-Coumate
Drug Type
Small molecular drug
Indication Prostate cancer [ICD9: 185; ICD10:C61] Phase 1 [547916]
Therapeutic Class
Anticancer Agents
Company
Amgen
Structure
Download
2D MOL

3D MOL
Formula
C14H15NO5S
Canonical SMILES
C1CCC2=C(CC1)C(=O)OC3=C2C=CC(=C3)OS(=O)(=O)N
InChI
1S/C14H15NO5S/c15-21(17,18)20-9-6-7-11-10-4-2-1-3-5-12(10)14(16)19-13(11)8-9/h6-8H,1-5H2,(H2,15,17,18)
InChIKey
DSLPMJSGSBLWRE-UHFFFAOYSA-N
PubChem Compound ID
5287541
PubChem Substance ID
7885447, 11041297, 14825625, 39320151, 46393268, 46507132, 46513478, 50666525, 57304391, 57359177, 96099876, 96099881, 103197875, 113869913, 134338898, 134340937, 135264139, 135626652, 142781879, 160965493, 163125312, 198963659, 204359724, 227502109, 244274726, 249802614, 252215038, 252451322
Target and Pathway
Target(s) Steryl-sulfatase Target Info Inhibitor [536200]
KEGG Pathway Steroid hormone biosynthesis
PathWhiz Pathway Androgen and Estrogen Metabolism
Reactome Glycosphingolipid metabolism
WikiPathways Estrogen metabolism
Vitamin D Receptor Pathway
Sphingolipid metabolism
References
Ref 547916Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020388)
Ref 536200Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor. Clin Cancer Res. 2006 Mar 1;12(5):1585-92.

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