Drug Information

Drug General Information
Drug ID
D05MXO
Former ID
DIB018498
Drug Name
19(R)-OH-PGE2
Synonyms
19(R)-hydroxy-PGE2; 19R-(OH)-PGE2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539247]
Structure
Download
2D MOL
Formula
C20H32O6
InChI
InChI=1S/C20H32O6/c1-14(21)7-6-8-15(22)11-12-17-16(18(23)13-19(17)24)9-4-2-3-5-10-20(25)26/h2,4,11-12,14-17,19,21-22,24H,3,5-10,13H2,1H3,(H,25,26)/b4-2-,12-11+/t14-,15+,16-,17-,19-/m1/s1
InChIKey
WTJYDBMHYPQFNJ-ZUVVJKHESA-N
PubChem Compound ID
5283038
PubChem Substance ID
4265967, 7979742, 11038697, 14755210, 26754832, 39316455, 57358814, 78622088, 104046452, 113858910, 126524216, 135651384, 137638303, 137767943, 179205581, 228722898, 241115417, 252464555
Target and Pathway
Target(s) Prostaglandin E2 receptor, EP4 subtype Target Info Agonist [534595]
Prostaglandin E2receptor, EP2 subtype Target Info Agonist [534595]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancerhsa04024:cAMP signaling pathway
Pathways in cancer
NetPath Pathway FSH Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Prostanoid ligand receptors
G alpha (s) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Ovarian Infertility Genes
GPCR downstream signaling
References
Ref 539247(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1947).
Ref 534595Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41.

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