Drug Information

Drug General Information
Drug ID
D05MPS
Former ID
DNC014566
Drug Name
MYOSEVERIN
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526222]
Structure
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2D MOL

3D MOL
Formula
C24H28N6O2
Canonical SMILES
CC(C)N1C=NC2=C1N=C(N=C2NCC3=CC=C(C=C3)OC)NCC4=CC=C(C=C4<br />)OC
InChI
1S/C24H28N6O2/c1-16(2)30-15-27-21-22(25-13-17-5-9-19(31-3)10-6-17)28-24(29-23(21)30)26-14-18-7-11-20(32-4)12-8-18/h5-12,15-16H,13-14H2,1-4H3,(H2,25,26,28,29)
InChIKey
IDCOTQWQVPRTNK-UHFFFAOYSA-N
PubChem Compound ID
4273
Target and Pathway
Target(s) Tubulin beta Target Info Inhibitor [526222]
Tubulin Target Info Inhibitor [526222]
KEGG Pathway Phagosome
Gap junction
Pathogenic Escherichia coli infection
NetPath Pathway FSH Signaling Pathway
TCR Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Cytoskeletal regulation by Rho GTPase
Huntington disease
Reactome Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization?from the centrosome
Anchoring of the basal body to the plasma membrane
WikiPathways Parkin-Ubiquitin Proteasomal System pathway
Pathogenic Escherichia coli infection
Mitotic G2-G2/M phases
References
Ref 526222J Med Chem. 2001 Dec 20;44(26):4497-500.Synthesis and biological evaluation of myoseverin derivatives: microtubule assembly inhibitors.
Ref 526222J Med Chem. 2001 Dec 20;44(26):4497-500.Synthesis and biological evaluation of myoseverin derivatives: microtubule assembly inhibitors.

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