Drug Information
Drug General Information | |||||
---|---|---|---|---|---|
Drug ID |
D05KQE
|
||||
Former ID |
DIB003608
|
||||
Drug Name |
MK-287
|
||||
Synonyms |
L-680573; (-)-(S,S)-2-[3-(2-Hydroxyethylsulfonyl)-5-methoxy-4-propoxyphenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran
|
||||
Drug Type |
Small molecular drug
|
||||
Indication | Septic shock [ICD9: 785.52; ICD10:A41.9] | Discontinued in Phase 2 | [544956] | ||
Structure |
Download2D MOL |
||||
Formula |
C25H34O9S
|
||||
Canonical SMILES |
CCCOc1c(OC)cc(cc1S(=O)(=O)CCO)[C@@H]2CC[C@H](O2)c3cc(OC<br />)c(OC)c(OC)c3
|
||||
InChI |
1S/C25H34O9S/c1-6-10-33-25-22(31-4)14-17(15-23(25)35(27,28)11-9-26)19-8-7-18(34-19)16-12-20(29-2)24(32-5)21(13-16)30-3/h12-15,18-19,26H,6-11H2,1-5H3/t18-,19-/m0/s1
|
||||
InChIKey |
WXIDMVGKJBAEFP-OALUTQOASA-N
|
||||
CAS Number |
CAS 135947-75-0
|
||||
PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Platelet-activating factor receptor | Target Info | Antagonist | [531635], [534027] | |
NetPath Pathway | IL5 Signaling Pathway | ||||
Leptin Signaling Pathway | |||||
References | |||||
Ref 531635 | Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. | ||||
Ref 534027 | MK 287: a potent, specific, and orally active receptor antagonist of platelet-activating factor. J Lipid Mediat. 1993 Jun;7(2):115-34. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.