Drug General Information
Drug ID
D05KNG
Former ID
DIB011063
Drug Name
ALB-109564(a)
Synonyms
ALB-109564; Vinca alkaloid analogs (cancer), Albany Molecular Research
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [522388]
Company
Bessor-brightwaters pharma
Structure
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2D MOL

3D MOL

Canonical SMILES
Cl.Cl.C(=O)([C@]1(c2c(c3c([nH]2)ccc(c3)SC)CCN2C[C@](C[C<br />@@H](C1)C2)(O)CC)c1cc2[C@@]34[C@H]([C@]([C@@H]([C@]5([C<br/>@@H]3N(CC4)CC=C5)CC)OC(=O)C)(C(=O)OC)O)N(c2cc1OC)C)OC
Target and Pathway
Target(s) Tubulin beta Target Info Modulator
KEGG Pathway Phagosome
Gap junction
Pathogenic Escherichia coli infection
NetPath Pathway FSH Signaling Pathway
TCR Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Cytoskeletal regulation by Rho GTPase
Huntington disease
Reactome Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization?from the centrosome
Anchoring of the basal body to the plasma membrane
WikiPathways Parkin-Ubiquitin Proteasomal System pathway
Pathogenic Escherichia coli infection
Mitotic G2-G2/M phases
References
Ref 522388ClinicalTrials.gov (NCT00724100) A Trial of ALB 109564(a) in Subjects With Advanced Solid Tumors. U.S. National Institutes of Health.

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