| Drug General Information |
| Drug ID |
D05JPW
|
| Former ID |
DNC005227
|
| Drug Name |
2-(4-Hydroxy-phenyl)-7-methoxy-benzooxazol-5-ol
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C14H11NO4
|
| Canonical SMILES |
COC1=C2C(=CC(=C1)O)NC(=C3C=CC(=O)C=C3)O2
|
| InChI |
1S/C14H11NO4/c1-18-12-7-10(17)6-11-13(12)19-14(15-11)8-2-4-9(16)5-3-8/h2-7,15,17H,1H3
|
| InChIKey |
MAIIIGSGJUHYMP-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Estrogen receptor beta |
Target Info |
Inhibitor |
[1]
|
|---|
| Estrogen receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Estrogen signaling pathway
|
|
Prolactin signaling pathwayhsa04915:Estrogen signaling pathway
|
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Prolactin signaling pathway
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Thyroid hormone signaling pathway
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Endocrine and other factor-regulated calcium reabsorption
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Proteoglycans in cancer
|
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NetPath Pathway
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FSH Signaling Pathway
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EGFR1 Signaling Pathway
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RANKL Signaling Pathway
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Pathway Interaction Database
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Plasma membrane estrogen receptor signaling
|
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Validated nuclear estrogen receptor beta network
|
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Validated nuclear estrogen receptor alpha networksmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
|
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Signaling events mediated by HDAC Class II
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LKB1 signaling events
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Regulation of Telomerase
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ATF-2 transcription factor network
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AP-1 transcription factor network
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FOXM1 transcription factor network
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Validated nuclear estrogen receptor alpha network
|
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Signaling mediated by p38-alpha and p38-beta
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FOXA1 transcription factor network
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Reactome
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Nuclear Receptor transcription pathwayR-HSA-1251985:Nuclear signaling by ERBB4
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Nuclear Receptor transcription pathway
|
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WikiPathways
|
SIDS Susceptibility Pathways
|
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Ovarian Infertility Genes
|
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Integrated Pancreatic Cancer Pathway
|
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Nuclear ReceptorsWP712:Estrogen signaling pathway
|
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Nuclear Receptors Meta-Pathway
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Estrogen Receptor Pathway
|
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Signaling by ERBB4
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JAK/STAT
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Leptin signaling pathway
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miR-targeted genes in muscle cell - TarBase
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Integrated Breast Cancer Pathway
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|
Nuclear Receptors
|
| References |
| REF 1 | J Med Chem. 2004 Oct 7;47(21):5021-40.Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. |
|---|
