TTD | Drug: D05HYV

Drug General Information
Drug ID	D05HYV
Former ID	DIB020982
Drug Name	SR48527
Synonyms	SR-48527; SR 48527
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538960]
Structure		Download 2D MOL
Formula	C29H29ClN4O5
InChI	InChI=1S/C29H29ClN4O5/c1-38-24-9-6-10-25(39-2)26(24)23-16-21(28(35)32-27(29(36)37)17-7-4-3-5-8-17)33-34(23)22-13-14-31-20-15-18(30)11-12-19(20)22/h6,9-17,27H,3-5,7-8H2,1-2H3,(H,32,35)(H,36,37)/t27-/m0/s1
InChIKey	PXNTUYAGLGTUKX-MHZLTWQESA-N
PubChem Compound ID	9915499
PubChem Substance ID	14885977, 24194784, 45987152, 80409071, 103593305, 135651078, 136350388
Target and Pathway
Target(s)	Neurotensin receptor type 1	Target Info	Antagonist	[533717]
KEGG Pathway	Calcium signaling pathway
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 538960	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1581).
Ref 533717	[3H]SR 48692, the first nonpeptide neurotensin antagonist radioligand: characterization of binding properties and evidence for distinct agonist and antagonist binding domains on the rat neurotensin receptor. Mol Pharmacol. 1995 May;47(5):1050-6.

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Drug Information