| Drug General Information |
| Drug ID |
D05HQX
|
| Former ID |
DNC003874
|
| Drug Name |
4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)-phenol
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| Drug Type |
Small molecular drug
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| Indication |
Discovery agent
|
Investigative |
[1]
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|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C16H17N3O
|
| Canonical SMILES |
CCCCC1=C2C(=NC=CN2)NC1=C3C=CC(=O)C=C3
|
| InChI |
1S/C16H17N3O/c1-2-3-4-13-14(11-5-7-12(20)8-6-11)19-16-15(13)17-9-10-18-16/h5-10,17H,2-4H2,1H3,(H,18,19)
|
| InChIKey |
AYIIQABSVDIZSY-UHFFFAOYSA-N
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| PubChem Compound ID |
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| Target and Pathway |
| Target(s) |
G1/S-specific cyclin E1 |
Target Info |
Inhibitor |
[1]
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|---|
| Cyclin-A2 |
Target Info |
Inhibitor |
[1]
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| Cell division protein kinase 2 |
Target Info |
Inhibitor |
[1]
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KEGG Pathway
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Cell cycle
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Oocyte meiosis
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p53 signaling pathway
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PI3K-Akt signaling pathway
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Hepatitis B
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Measles
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Pathways in cancer
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Viral carcinogenesis
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MicroRNAs in cancer
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Prostate cancer
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Small cell lung cancerhsa03030:DNA replication
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Base excision repair
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Nucleotide excision repair
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Mismatch repair
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HTLV-I infectionhsa04068:FoxO signaling pathway
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Progesterone-mediated oocyte maturation
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Herpes simplex infection
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Epstein-Barr virus infection
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Small cell lung cancer
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NetPath Pathway
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IL2 Signaling Pathway
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TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
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PANTHER Pathway
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Cell cycle
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Parkinson disease
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p53 pathway
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p53 pathway feedback loops 2P00059:p53 pathway
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p53 pathway feedback loops 2
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Pathway Interaction Database
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Signaling events mediated by PRL
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E2F transcription factor network
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mTOR signaling pathway
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FOXM1 transcription factor network
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BARD1 signaling events
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PLK3 signaling events
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Regulation of retinoblastoma proteinsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
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p73 transcription factor network
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ATR signaling pathway
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IL2-mediated signaling events
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FoxO family signaling
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p53 pathway
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Regulation of retinoblastoma protein
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PathWhiz Pathway
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Nucleotide Excision Repair
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Reactome
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E2F mediated regulation of DNA replication
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G0 and Early G1
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SCF(Skp2)-mediated degradation of p27/p21
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DNA Damage/Telomere Stress Induced Senescence
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Cyclin E associated events during G1/S transition
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G1/S-Specific Transcription
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p53-Dependent G1 DNA Damage ResponseR-HSA-113510:E2F mediated regulation of DNA replication
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Cdc20:Phospho-APC/C mediated degradation of Cyclin A
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Regulation of APC/C activators between G1/S and early anaphase
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Senescence-Associated Secretory Phenotype (SASP)
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Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
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Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
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HDR through Homologous Recombination (HRR)
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Processing of DNA double-strand break ends
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Dual Incision in GG-NER
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Dual incision in TC-NER
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Gap-filling DNA repair synthesis and ligation in TC-NER
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G2 Phase
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Orc1 removal from chromatin
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Cyclin A/B1 associated events during G2/M transition
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Cyclin A:Cdk2-associated events at S phase entryR-HSA-1538133:G0 and Early G1
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Activation of ATR in response to replication stress
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p53-Dependent G1 DNA Damage Response
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Cyclin A:Cdk2-associated events at S phase entry
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Meiotic recombination
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Factors involved in megakaryocyte development and platelet production
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WikiPathways
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DNA Damage Response
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ID signaling pathway
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G1 to S cell cycle control
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Retinoblastoma (RB) in Cancer
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Integrated Pancreatic Cancer Pathway
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Parkinsons Disease Pathway
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Parkin-Ubiquitin Proteasomal System pathway
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Signaling Pathways in Glioblastoma
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TSH signaling pathway
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Mitotic G1-G1/S phases
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Cell Cycle
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miRNAs involved in DNA damage response
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miRNA Regulation of DNA Damage Response
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Androgen receptor signaling pathwayWP615:Senescence and Autophagy in Cancer
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Mismatch repair
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DNA Replication
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EGF/EGFR Signaling Pathway
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S Phase
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Nifedipine Activity
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Primary Focal Segmental Glomerulosclerosis FSGS
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Nucleotide Excision Repair
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Telomere Maintenance
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Synthesis of DNA
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Base Excision RepairWP707:DNA Damage Response
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M/G1 Transition
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Meiotic Recombination
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Aryl Hydrocarbon Receptor
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ATM Signaling Pathway
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Spinal Cord Injury
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Oncostatin M Signaling Pathway
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Prostate Cancer
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Integrated Breast Cancer Pathway
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Integrated Cancer pathway
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Regulation of DNA replication
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Mitotic G2-G2/M phases
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Factors involved in megakaryocyte development and platelet production
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APC/C-mediated degradation of cell cycle proteins
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Cell Cycle Checkpoints
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| References |
| REF 1 | J Med Chem. 2003 Jan 16;46(2):222-36.Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. |
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