Drug Information

Drug General Information
Drug ID
D05HNB
Former ID
DNC003689
Drug Name
LY-282210
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533960]
Structure
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2D MOL

3D MOL
Formula
C30H28O10
Canonical SMILES
CCC1=C(C=C(C(=C1)C(=O)C)O)OCCCOC2=C(C3=C(C=C2)C(=O)C4=C<br />(O3)C=CC(=C4)C(=O)O)CCC(=O)O
InChI
1S/C30H28O10/c1-3-17-13-21(16(2)31)23(32)15-26(17)39-12-4-11-38-24-9-6-20-28(35)22-14-18(30(36)37)5-8-25(22)40-29(20)19(24)7-10-27(33)34/h5-6,8-9,13-15,32H,3-4,7,10-12H2,1-2H3,(H,33,34)(H,36,37)
InChIKey
HGMXXGVRUCAMMK-UHFFFAOYSA-N
PubChem Compound ID
9893718
Target and Pathway
Target(s) Leukotriene B4 receptor 2 Target Info Inhibitor [533960]
Leukotriene B4 receptor 1 Target Info Inhibitor [533960]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Leukotriene receptors
G alpha (q) signalling eventsR-HSA-391906:Leukotriene receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP80:Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Spinal Cord Injury
References
Ref 533960J Med Chem. 1993 Nov 26;36(24):3982-4.Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists.
Ref 533960J Med Chem. 1993 Nov 26;36(24):3982-4.Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists.

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