Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05GQH
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| Former ID |
DIB010077
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| Drug Name |
ADX-88178
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| Synonyms |
ADX-88178; MGluR4 positive modulators, Addex/Merck; MGluR4 PAM modulators (oral, Parkinson's disease/anxiety); MGluR4 PAM modulators (oral, Parkinson's disease/anxiety), Addex/Merck & Co
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| Drug Type |
Small molecular drug
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| Indication | Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] | Investigative | [1] | ||
| Company |
Addex Pharmaceuticals SA
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| Structure |
|
Download2D MOL |
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| Formula |
C12H12N6S
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| InChI |
InChI=1S/C12H12N6S/c1-7-3-4-13-11(16-7)18-12-17-10(8(2)19-12)9-5-14-15-6-9/h3-6H,1-2H3,(H,14,15)(H,13,16,17,18)
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| InChIKey |
MIQNXKWDQRNHAU-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Metabotropic glutamate receptor 4 | Target Info | Modulator | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Glutamatergic synapse | |||||
| Taste transduction | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Metabotropic glutamate receptor group III pathway | |||||
| Reactome | G alpha (i) signalling events | ||||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | ||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6238). | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 292). | ||||
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