Drug Information
Drug General Information | |||||
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Drug ID |
D05GJW
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Former ID |
DAP000565
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Drug Name |
Cladribine
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Synonyms |
Chlorodeoxyadenosine; Cladarabine; Cladaribine; Cladribina; Cladribinum; CldAdo; Leustat; Leustatin; Litak; Movectro;Mylinax; CL9; RWJ 26251; Leustatin (TN); RWJ-26251; Cladribine [USAN:INN:BAN]; RWJ-26251-000; Cladribine (JAN/USAN/INN); Leustatin, 2-chlorodeoxyadenosine, Cladribine; Adenosine, 2-chloro-2'-deoxy; (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol; 2 Chlorodeoxyadenosine; 2'-Deoxy-2-chloroadenosine; 2-CdA; 2-Chloro-2'-deoxy-beta-adenosine; 2-Chloro-2'-deoxyadenosine; 2-Chloro-6-amino-9-(2-deoxy-beta-D-erythropentofuranosyl)purine; 2-Chlorodeoxyadenosine; 2-chloro-6-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine; 2-chloro-deoxyadenosine
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Drug Type |
Small molecular drug
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Therapeutic Class |
Anticancer Agents
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Structure |
Download2D MOL |
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Formula |
C10H12ClN5O3
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InChI |
InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1
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InChIKey |
PTOAARAWEBMLNO-KVQBGUIXSA-N
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CAS Number |
CAS 4291-63-8
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PubChem Compound ID | |||||
PubChem Substance ID |
610461, 855756, 866156, 7848433, 7978577, 7978957, 8165006, 14799875, 14897807, 26719669, 26757803, 29287787, 46386544, 46504588, 48415788, 49865077, 49903916, 49903918, 50104045, 50446026, 56312468, 56312469, 56312470, 56312853, 56422184, 57309572, 57330593, 71821359, 87323981, 92308638, 92713835, 99218181, 99431527, 99437023, 103602769, 104350170, 118046705, 124659094, 124757075, 124800053, 124886798, 124886799, 125163879, 126624559, 126655830, 128966217, 131314655, 134337856, 134984314, 135683425
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SuperDrug ATC ID |
L01BB04
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SuperDrug CAS ID |
cas=004291638
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Target and Pathway | |||||
Target(s) | Adenosine deaminase | Target Info | Inhibitor | [535395], [536010] | |
NetPath Pathway | TCR Signaling Pathway | ||||
IL2 Signaling Pathway | |||||
PANTHER Pathway | Adenine and hypoxanthine salvage pathway | ||||
PathWhiz Pathway | Purine Metabolism | ||||
Reactome | Purine salvage | ||||
WikiPathways | Metabolism of nucleotides | ||||
References | |||||
Ref 468028 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4799). | ||||
Ref 536604 | Multiple sclerosis: current and future treatment options. Endocr Metab Immune Disord Drug Targets. 2007 Dec;7(4):292-9. |
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