| Drug General Information |
| Drug ID |
D05FXD
|
| Former ID |
DIB019563
|
| Drug Name |
compound 66
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C22H19N5O4
|
| InChI |
InChI=1S/C22H19N5O4/c1-12-8-9-13(28)10-14(12)16-11-26-18-19(25(2)22(30)24-20(18)29)23-21(26)27(16)15-6-4-5-7-17(15)31-3/h4-11,28H,1-3H3,(H,24,29,30)
|
| InChIKey |
JTWMOWRMSZZHDR-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
|
| Target and Pathway |
| Target(s) |
EPH receptor A7 |
Target Info |
Inhibitor |
[1]
|
|---|
| EPH receptor B1 |
Target Info |
Inhibitor |
[1]
|
| Ephrin type-B receptor 2 |
Target Info |
Inhibitor |
[1]
|
| Epha4 tyrosine kinase receptor |
Target Info |
Inhibitor |
[1]
|
| EPH receptor B3 |
Target Info |
Inhibitor |
[1]
|
| Epha3 tyrosine kinase receptor |
Target Info |
Inhibitor |
[1]
|
| EPH receptor A5 |
Target Info |
Inhibitor |
[1]
|
| Ephrin type-B receptor 4 |
Target Info |
Inhibitor |
[1]
|
| EPH receptor A8 |
Target Info |
Inhibitor |
[1]
|
| EPH receptor A1 |
Target Info |
Inhibitor |
[1]
|
| Ephrin type-A receptor 2 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Axon guidancehsa04360:Axon guidancehsa04360:Axon guidancehsa04360:Axon guidancehsa04014:Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
PI3K-Akt signaling pathway
|
|
Axon guidance
|
|
NetPath Pathway
|
IL2 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
|
|
PANTHER Pathway
|
Angiogenesis
|
|
Pathway Interaction Database
|
EPHB forward signaling
|
|
EphrinB-EPHB pathway
|
|
Syndecan-2-mediated signaling events
|
|
Ephrin B reverse signalingephrina_ephapathway:EphrinA-EPHA pathway
|
|
EPHA forward signalingephrina_ephapathway:EphrinA-EPHA pathway
|
|
EPHA forward signalingephbfwdpathway:EPHB forward signaling
|
|
Arf6 signaling events
|
|
Direct p53 effectors
|
|
EPHA forward signaling
|
|
Stabilization and expansion of the E-cadherin adherens junction
|
|
EPHA2 forward signaling
|
|
Reactome
|
EPH-Ephrin signaling
|
|
L1CAM interactions
|
|
EPHB-mediated forward signaling
|
|
EPH-ephrin mediated repulsion of cellsR-HSA-2682334:EPH-Ephrin signaling
|
|
EPHA-mediated growth cone collapse
|
|
EPH-ephrin mediated repulsion of cells
|
|
WikiPathways
|
Transcriptional activation by NRF2
|
|
NLR Proteins
|
|
Regulation of Microtubule Cytoskeleton
|
|
L1CAM interactionsWP2854:Gene regulatory network modelling somitogenesis
|
|
Spinal Cord InjuryWP2884:NRF2 pathwayWP2877:Vitamin D Receptor PathwayWP2884:NRF2 pathway
|
| References |
| REF 1 | Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4). J Med Chem. 2009 Oct 22;52(20):6433-46. |
|---|
